| 肾性高血压大鼠血浆内皮素，一氧化氮含量变化及老年降压冲剂对其影响 |
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| 引用本文： | 卢昌均,黄小军,陈宝田.肾性高血压大鼠血浆内皮素，一氧化氮含量变化及老年降压冲剂对其影响[J].中国现代医学杂志,2001,11(9):8-9. |
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| 作者姓名： | 卢昌均 黄小军 陈宝田 |
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| 作者单位： | 1. 解放军477医院神经科襄樊
2. 第一军医大学南方医院 |
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| 摘 要： | 目的探讨肾性高血压大鼠模型(RHR)血浆内皮素(ET),一氧化氮(NO)含量变化与高血压的关系以及老年降压冲剂的作用.方法建立RHR模型,随机分为5组,观察ET、NO含量变化.结果RHR血浆ET浓度显著升高(P＜0.01),而NO浓度显著下降(P＜0.01);血浆ET和NO有显著负相关(r=-0.984,P＜0.001);老年降压冲剂能升高血浆NO浓度,降低ET浓度.结论RHR高血压形成可能ET、NO起重要作用,ET-NO平衡调节可能是老年降压冲剂降压机能之一.
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| 关 键 词： | 肾性高血压大鼠模型 内皮素 一氧化氮 老年降压冲剂 |
| 修稿时间： | 2000年11月28 |
Change of Endothelin and Nitric Oxide in Renovascular Hypertension Rats and Treatment with Lnjychj |
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| Lu Changjun,Huang Xiaojun,Chen Baotian.Change of Endothelin and Nitric Oxide in Renovascular Hypertension Rats and Treatment with Lnjychj[J].China Journal of Modern Medicine,2001,11(9):8-9. |
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| Authors: | Lu Changjun Huang Xiaojun Chen Baotian |
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| Institution: | Lu Changjun,Huang Xiaojun,Chen Baotian Department of Neurology,477th Hospital of PLA,Xiangfan 441003 |
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| Abstract: | Objective:To study the change of endothelin (ET) and Nitric oxide(NO) in hypertension rats nd treatment with LNJYCHJ.Methods:The rat models of renovascular hypertension(RHR) were established in study in order to in vestigate parameter in hypertension group compared to naive control group.Results:Plasma ET in RHR had significantly increased (P<0.01),but NO in RHR had significantly decreased (P<0.01).Plasma ET and NO in RHR had a significantly negative correlation (r=-0.984,P<0.001).LNJYCHJ decreased the plasma ET concentration,while it increased the plasma NO Concentration.Conclusions:ET and NO might participate in mechanism of hypertension in RHR model.The regulation of ET-NO balance might be one of the mechanisms of anti-hypatension of LNJYCHJ. |
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| Keywords: | Renovascular Hypertension Rats Endothelin Nitric Oxide LNJYCHJ |
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