| miR-122的研究进展 |
| |
| 引用本文： | 李绍祥,李浩然,张成平,曹建彪. miR-122的研究进展[J]. 昆明医学院学报, 2012, 33(9): 146-150 |
| |
| 作者姓名： | 李绍祥 李浩然 张成平 曹建彪 |
| |
| 作者单位： | 北京军区总医院全军肝病治疗中心,北京,100700 |
| |
| 基金项目： | 国家自然科学基金资助项目(30872353) |
| |
| 摘 要： | miR-122是一种专一表达于肝脏的miRNA,在生理状态下参与精子发生、肝细胞发育、肝细胞表型、分化代谢,以及肝细胞应急应答等基本生命活动过程.在病理状态下,miR-122有促进HCV复制和翻译的作用,还可促进肿瘤细胞的凋亡,在HCC发生、发展过程中发挥抑癌基因样作用.
|
| 关 键 词： | 微小RNA miR-122 RNA调控 |
Research Progress of miR-122 |
| |
| LI Shao-xiang , LI Hao-ran , ZHANG Cheng-ping , CAO Jian-biao. Research Progress of miR-122[J]. Journal of Kunming Medical College, 2012, 33(9): 146-150 |
| |
| Authors: | LI Shao-xiang LI Hao-ran ZHANG Cheng-ping CAO Jian-biao |
| |
| Affiliation: | (Institute of Hepatology of PLA,Beijing Military General Hospital,Beijing 100700,China) |
| |
| Abstract: | miR-122,a kind of miRNA specifically expressing in the liver,under physiological conditions is involved in basic life activities such as spermatogenesis,development,phenotype,differentiation,metabolism and cell response of liver cells.While under pathological conditions,in addition to promoting replication and translation of HCV,miR-122 also can induce apoptosis of tumor cells,playing the role like tumor suppressor gene in the development process of HCC. |
| |
| Keywords: | miRNA miR-122 Regulation of RNA |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
