带状疱疹患者单一核细胞Toll样受体3和9的表达

目的　探讨Toll样受体TLR3和TLR9在带状疱疹发病机制中的作用。方法　采用流式细胞仪检测40例带状疱疹患者外周血单一核细胞（PBMC）上TLR3和TLR9的表达水平。16例正常人群为对照组。结果 带状疱疹患者PBMC上TLR3和TLR9的表达水平均明显高于正常人对照组（ P < 0. 01）。带状疱疹患者PBMC上TLR3和TLR9的表达水平与发病时间存在负相关关系（ r值分别为- 6.23，- 5.88, P值均 < 0. 01） ,但与性别、年龄无相关性。带状疱疹患者PBMC上TLR3和TLR9表达在各年龄组间（< 40岁, 40 ~ 50岁, > 50岁），差异具有统计学意义（F = 3.410，P < 0. 01），且< 40岁年龄组TLR3和TLR9的表达明显高于其他两组。结论　TLR3和TLR9可能参与带状疱疹发病。

Expressions of Toll-like receptor 3 and 9 in peripheral mononuclear cells from patients with herpes zoster

Objective To investigate the roles of Toll-like receptor （TLR） 3 and 9 in herpes zoster （HZ）． Methods Venous blood samples were collected from 40 patients with HZ and 16 normal human controls． Flow cyometry was used to detect the expressions of TLR3 and TLR9 in peripheral blood mononuclear cells （PBMCs） from these subjects. Results The percentages of PBMCs expressing TLR3 and TLR9 were significantly higher in patients than in normal human controls （both P < 0.01）．The expression levels of TLR3 and TLR9 in PBMCs were negatively correlated with the age of onset （r = －6.23, －5.88 respectively, both P < 0. 01）, but uncorrelated with gender or age. There was a significant difference in the expression levels of TLR3 and TLR9 in PBMCs between different age groups （< 40 years, 40-50 years, > 50 years） of patients with HZ （F = 3.410, P < 0.01）, with the strongest expression observed in patients younger than 40 years. Conclusion TLR3 and TLR9 may participate in the pathogenesis of HZ.