加替沙星滴眼液对角膜异物剔除术后抗菌效果的临床研究

目的观察加替沙星滴眼液对角膜异物剔除术后的抗菌效果及安全性。方法采用随机、双盲和平行对照的方法，将200侧眼角膜异物患者随机分为加替沙星治疗组和左氧氟沙星对照组，每组各100侧。每个患者行角膜异物剔除术后，试验组应用加替沙星滴眼液，对照组应用海伦（左氧氟沙星）滴眼液，每次1滴，每2h1次，每日6次滴眼，观察两组用药后的抑菌效果及其安全性指标。结果试验组和对照组的临床疗效总有效率分别为96％和83％，差异有统计学意义（P〈0．05）。细菌清除率试验组和对照组分别为96.30％和85．37％。试验组和对照组的细菌清除率差异有统计学意义（P〈0．05）。结论加替沙星滴眼液与海伦滴眼液相比，抗菌谱更广，抗菌活性更强，对角膜异物剔除术后的治疗，临床抗菌效果明确，无不良反应。

Anti-biotical effect of gatifloxacin eyedrops after extraction of corneal foreign body

Objective To evaluate the efficacy and safety of gatifloxacin eyedrops after the extraction of corneal foreign body. Methods A randomized,double-blind and parallel study was conducted on 200 cases with,who had extracted corneal foreign body. Gatifloxacin eyedrops and Hailun eyedrops(levofloxacin eyedrops),six times a day,were administered in test and control groups,respectively. All patients were observed for 7 days. The clinical effectiveness and reaction to drugs after administration were assessed as the ...