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Polymorphisms in glutathione S-transferase genes increase risk of prostate cancer biochemical recurrence differentially by ethnicity and disease severity |
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| Authors: | Nora L. Nock Cathryn Bock Christine Neslund-Dudas Jennifer Beebe-Dimmer Andrew Rundle Deliang Tang Michelle Jankowski Benjamin A. Rybicki |
| Affiliation: | (1) Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA;(2) Center for Transdisciplinary Research on Energetics and Cancer, Case Western Reserve University, Cleveland, OH, USA;(3) Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA;(4) Department of Biostatistics and Epidemiology, Henry Ford Health System, 1 Ford Place, 3E, Detroit, MI 48202, USA;(5) Department of Environmental Health Sciences, Columbia University, New York, NY, USA |
| Abstract: | ObjectiveGenetic polymorphisms that modify the detoxifying activity of glutathione S-transferases (GSTs) can affect the level of carcinogenic metabolites created by endogenous steroid hormones and exogenous chemical substances. Although the GSTM1 null genotype has been shown to increase prostate cancer mortality in Caucasians, potential associations between GST polymorphisms and prostate cancer biochemical recurrence (BCR) have not been well studied, particularly in African-Americans. |
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