| 重症肌无力患者HLA－DRB_1等位基因分析 |
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| 引用本文： | 高波廷,杨明山,龚非力,姜晓丹.重症肌无力患者HLA－DRB_1等位基因分析[J].中国神经精神疾病杂志,1995(1). |
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| 作者姓名： | 高波廷 杨明山 龚非力 姜晓丹 |
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| 作者单位： | 同济医科大学附属同济医院神经科，同济医科大学免疫学教研室 |
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| 摘 要： | 作者应用ＰＣＲ－ＳＳＰ方法，对３４例重症肌无力（ＭＧ）患者和８６名健康汉人ＨＬＡ－ＤＲＢ１等位基因进行分析、研究，结果发现，ＭＧ病人组ＭＲＢ１区域内０９０１、１３０１两对等位基因的频率明显高于对照组（ＲＲ分别为１６．９４４和５．５１２，Ｐ均＜０．０１）。其中８例伴有胸腺瘤的ＭＧ患者除０９０１、１３０１两对等位基因频率增高外，０４０１基因频率亦明显高于正常对照组（ＲＲ分别为３９．５０３、４．９８０和４．０００．Ｐ均＜０．０１）。作者认为，ＭＧ发病可能与ＨＬＡ－ＤＲＢ１区域内０９０１、１３０１和０４０１三对等住基因相关联。
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| 关 键 词： | 重症肌无力，HLA－DRB1等位基因，PCR－SSP方法，发病机理 |
HLA-DRBI genotypes in Chinese myasthe nia gravis. |
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| Gao Poting,et al..HLA-DRBI genotypes in Chinese myasthe nia gravis.[J].Chinese Journal of Nervous and Mental Diseases,1995(1). |
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| Authors: | Gao Poting |
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| Abstract: | We studied HLA-DRBI alleies in 34Chinese patients with myasthenia gravis(MG)and 86 'healthy Hanian controls using PCR SSP(sequencespecific primers ). It was found that the frequency of DRBI 0901 and 1301alleies was significantly higher (R = 16.944,5.512 respectively; p <0.01). in 34 MG patients compared with the controls. An increasing frequency of DRBI 0401 allele in SMG patients with thymoma (R =4.000, p<0.ol). was also observed. It is suggested that there may be an asociation between HLA -- DRBI 0901. 1301and 0401 alleies with myasthenia gravis in Chinese. |
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| Keywords: | Myasthenia gravis HLADRBI allele PCR-SSP Pathogenesis |
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