特利加压素联合生长抑素治疗肝硬化失代偿期并急性上消化道大出血的疗效观察

目的 观察临床应用特利加压素联合生长抑素治疗肝硬化失代偿期并急性上消化道大出血的疗效。方法 选取2014年1月-2016年6月在上海交通大学医学院附属第九人民医院进行治疗的69例肝硬化失代偿期并急性上消化道大出血患者，按随机数字表法分为对照组33例和观察组36例，对照组患者给予生长抑素治疗，观察组在对照组治疗基础上联合应用特利加压素治疗，两组患者均以治疗1周为1疗程。对比分析两组患者止血效果及不良反应发生情况，并观察记录两组患者输血量、止血时间、住院时间、大便隐血转阴时间以及血压和尿量恢复时间。结果 两组患者治疗后止血效果比较，观察组总有效率为94.4%，明显高于对照组的75.8%，差异有统计学意义（P<0.05）。两组患者治疗后输血量、止血时间、住院时间、大便隐血转阴时间以及血压和尿量恢复时间比较，观察组均明显低于对照组，差异有统计学意义（P<0.05）。治疗后两组患者不良反应发生率及病死率比较均无明显差异。结论 临床应用特利加压素联合生长抑素治疗肝硬化失代偿期并急性上消化道大出血止血效果显著，可有效改善预后，且安全性高，可在临床推广应用。

The efficacy of Tripsin combined growth inhibition in treatment of decompensated liver cirrhosis combined with upper gastrointestinal bleeding

Objective The efficacy of tripsin combined with growth inhibition in treatment of decompensated liver cirrhosis combined with upper gastrointestinal bleeding. Methods 69 cases decompensated liver cirrhosis combined with upper gastrointestinal bleeding from Jan. 2014 to June 2016 in our hospital were chosen and divided into the control group and observation group. The control group were given inhibition, the observation group were given inhibition, the efficacy of two groups were compared. Results The hemostatic effect total efficacy of two groups after treatment of observation group were obvious higher than control group (P < 0.05). The blood transfusions amount, bleeding duration, the inpatient time, the defecate revulating time, blood pressure and urinary recovery time of observation group were shorter than control group (P < 0.05). The adverse reaction rate and case fatality rate of two groups had no significant difference. Conclusion The tripsin combined with inhibition in treatment of decompensated liver cirrhosis combined with upper gastrointestinal bleeding had great efficacy and safety, which could improve prognosis, be worth of clinical promotion.