| 长骨釉质瘤10例临床病理形态及免疫表型分析 |
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| 引用本文： | 丁宜,孙晓淇,孟淑琴,鱼锋,黄啸原. 长骨釉质瘤10例临床病理形态及免疫表型分析[J]. 诊断病理学杂志, 2011, 18(3). DOI: 10.3969/j.issn.1007-8096.2011.03.003 |
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| 作者姓名： | 丁宜 孙晓淇 孟淑琴 鱼锋 黄啸原 |
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| 作者单位： | 1. 北京积水潭医院,病理科,北京100035
2. 北京积水潭医院,骨肿瘤科,北京100035 |
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| 摘 要： | 目的 研究釉质瘤临床病理特点,分析免疫组化在釉质瘤、骨性纤维结构不良(OFD)样釉质瘤及骨性纤维结构不良的诊断与鉴别诊断中的作用,探讨三者之间的关系.方法 回顾性分析发生于胫、腓骨的釉质瘤10例,其中OFD样釉质瘤2例;并与胫、腓骨发生的15例OFD进行比较.结合文献讨论这些病例的临床表现、病理形态、免疫组化及随访结果.结果 10例釉质瘤均位于胫、腓骨皮质,其中8例镜下有明确的上皮样分化,2例镜下见骨性纤维结构不良背景下散在少数活跃的上皮样梭形细胞,经免疫组化检测后支持OFD样釉质瘤.釉质瘤患者均行肿瘤广泛切除,随访4个月～5年(平均4.3年)无复发.OFD患者接受刮除植骨治疗,随访3个月～3年(平均2.2年)无复发.结论 釉质瘤为少数低度恶性骨原发肿瘤之一,诊断依据为镜下见到明确的上皮样成分并经免疫组化支持.需与临床、影像学密切结合并充分取材行上皮抗原免疫组化检测方能避免漏诊.
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| 关 键 词： | 釉质瘤 骨性纤维结构不良样釉质瘤 骨性纤维结构不良 免疫组化 |
Adamantinomas involving long bones: clinicopathological and immunophenotypic analyses of 10 cases |
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| DING Yi,SUN Xiao-qi,MENG Shu-qin,YU Feng,HUANG Xiao-yuan. Adamantinomas involving long bones: clinicopathological and immunophenotypic analyses of 10 cases[J]. Chinese Journal of Diagnostic Pathology, 2011, 18(3). DOI: 10.3969/j.issn.1007-8096.2011.03.003 |
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| Authors: | DING Yi SUN Xiao-qi MENG Shu-qin YU Feng HUANG Xiao-yuan |
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| Affiliation: | DING Yi1,SUN Xiao-qi1,MENG Shu-qin1,YU Feng2,HUANG Xiao-yuan1(1.Department of Pathology,2.Department of Oncology,Jishuitan Hospital,Beijing 100035,China) |
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| Abstract: | Objective To explore the clinicopathological features of adamantinoma,and to confirm the role of immunohistochemical stains in the diagnosis and differential diagnosis of osteofibrous dysplasia(OFD)-like adamantinoma from OFD,with special focus on OFD-like adamantinioma and the correlation among these three diseases.Methods Ten cases of adamantinoma on tibia and fibula and 15 OFD on tibia and fibula were collected from 2005-2010 in this hospital,their clinical manifestations,pathological features,immunohist... |
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| Keywords: | Adamantinoma Osteofibrous dysplasia-like admantinoma Osteofibrous dysplasia Immunohistiochemistry |
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