| 甲状腺乳头状增生活跃与微小乳头状癌的诊断与鉴别诊断 |
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| 引用本文： | 佟杰,罗杰,笪冀平,王跃,张红雷,张敏.甲状腺乳头状增生活跃与微小乳头状癌的诊断与鉴别诊断[J].诊断病理学杂志,2011,18(3). |
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| 作者姓名： | 佟杰 罗杰 笪冀平 王跃 张红雷 张敏 |
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| 作者单位： | 卫生部中日友好医院病理科,北京,100029 |
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| 摘 要： | 目的 探讨甲状腺乳头状增生活跃与微小乳头状癌(PMC)的诊断与鉴别诊断.方法 收集PMC 100例,结节性甲状腺肿伴乳头状增生活跃53例.对比两者病理形态特征、流行病学及外科治疗方式,并检测CK19、HBME-1、galectin-3、CD56和p63的表达.结果 100%(53/53)的乳头状增生活跃出现具有纤维血管轴心的真性乳头,73.6%(39/53)伴2级及以上分支.无1例出现典型毛玻璃核、核明显异型重叠、包涵体等微小乳头状癌的细胞核特征,亦无间质硬化及浸润特征.甲状腺PMC中98.6%(73/74)CK19、HBME-1和galectin-3出现弥漫强阳性,而乳头状增生活跃组中无1例出现.结论 乳头状增生活跃可出现2级分支的真性乳头,但不出现典型毛玻璃核、核异型、核内包涵体等微小乳头状癌的典型细胞学特征,把不具有细胞学特征的真性乳头诊为乳头状癌一定要慎重.CK19、HBME-1、galectin-3三者弥漫强阳性是鉴别乳头状增生活跃及微小乳头状癌的非常有意义的指标.
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| 关 键 词： | 甲状腺 微小乳头状癌 乳头状增生 |
Histopathological and differential diagnosis of thyroid papillary hyperplasia and micropapillary carcinoma |
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| TONG Jie,LUO Jie,DA Ji-ping,WANG Yue,ZHANG Hong-lei,ZHANG Min.Histopathological and differential diagnosis of thyroid papillary hyperplasia and micropapillary carcinoma[J].Chinese Journal of Diagnostic Pathology,2011,18(3). |
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| Authors: | TONG Jie LUO Jie DA Ji-ping WANG Yue ZHANG Hong-lei ZHANG Min |
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| Institution: | TONG Jie,LUO Jie,DA Ji-ping,WANG Yue,ZHANG Hong-lei,ZHANG Min(Department of Pathology,China-Japan Friendship Hospital,Beijing 100029,China) |
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| Abstract: | Purpose To investigate the histopathological and differential diagnosis of thyroid papillary hyperplasia and micropapillary carcinoma.Methods The comparisons between 100 micropapillary carcinomas and 53 nodular goiters with foci of papillary hyperplasia were made based on their epidemiological and pathological characteristics,surgical management and the expression of CK19,HBME-1,galectin-3,CD56 and p63.Results Histopathologically,all the papillary thyroid hyperplasia tissues(53/53) contained the papillary s... |
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| Keywords: | CK19 HBME-1 galectin-3 CD56 p63 |
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