| 套式PCR检测骨髓移植人巨细胞病毒感染的研究 |
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| 引用本文： | 步恒富,马立人,刘志红,张蕊芳,刘耀清,王全立,黎伟明.套式PCR检测骨髓移植人巨细胞病毒感染的研究[J].中国公共卫生学报,1996(2). |
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| 作者姓名： | 步恒富 马立人 刘志红 张蕊芳 刘耀清 王全立 黎伟明 |
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| 作者单位： | 军事医学科学院放射医学研究所，吉林省卫生防疫站，白求恩医科大学基础医学博士后流动站 |
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| 摘 要： | 骨髓移植受体由于免疫抑制或免疫缺陷诱发人巨细胞病毒感染常常造成移植失败。应用套式ＰＣＲ对骨髓移植３３例受体和９８例供体检测发现，受体人巨细胞病毒的感染率（７５．８％，２５／３３）明显高于普通正常人（５７％，５６／９８），移植后４０天可达９３．９％（３１／３３），呈感染上升趋势。结果提示有必要在ＢＭＴ时对供受体进行人巨细胞病毒感染检测，便于ＢＭＴ术前选择和术后治疗，以提高移植的成功率。
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| 关 键 词： | 人巨细胞病毒，骨髓移植，套式PCR |
Study of Human Cytomegalovirus Infection in Bone Marrow Transplantation by Nested Polymerals Chain Reaction |
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| Authors: | Bu Hengfu |
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| Institution: | Bu Hengfu,et al., |
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| Abstract: | Human cytomegalovirus (HCMV) infection is often found in the immunodeficiency and/or immunosuppression patients after allogeneic bone marrow transplantation (BMT). HCMV positivity rate (75. 8%, 25/33) in the immunodeficiency or immunosupperssion recipients was 18. 8% higher than that of the ordinary population (57%, 56/98) and there was a rising trend of the positivity rate of HCMV infection in the recipients after BMT, up to 93. 9 % (31/33) in the 40th day after transplantation. The results mentioned above hint that it is necessary to enhance the detection of HCMV infection during BMT,which is helpful to the donor selection before BMT and the recipient therapy after BMT,and to the BMT success rate. |
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| Keywords: | Human cytomegalovirus Bone marrow transplantation Nested polymerase chain reaction |
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