Hepatitis C viraemia in adults with type 2 autoimmune hepatitis. |
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| Authors: | J A Garson M Lenzi C Ring F Cassani G Ballardini M Briggs R S Tedder F B Bianchi |
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| Affiliation: | Department of Medical Microbiology, School of Pathology, University College and Middlesex School of Medicine, London, United Kingdom. |
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| Abstract: | Sera from 14 patients with type 2 autoimmune hepatitis (anti-LKM1 positive) were investigated for evidence of hepatitis C virus (HCV) infection. Antibodies to HCV were detected in 13 patients by both commercial and "in-house" ELISAs and also by a second generation recombinant immunoblot assay. Nine of the 13 (69%) anti-HCV positive patients were shown to be viraemic by a polymerase chain reaction-based assay for serum HCV RNA. Neither anti-HCV nor serum HCV RNA were detected in any of 6 controls with primary biliary cirrhosis or in 39 healthy blood donors. These findings strongly suggest a role for HCV in the pathogenesis of type 2 autoimmune hepatitis. |
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| Keywords: | hepatitis C virus viraemia polymerase chain reaction autoimmune hepatitis LKM antibodies |
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