Biological properties of human mutant tumor necrosis factor-α |
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| Authors: | L. S. Sandakhchiev N. V. Merzlikin N. M. Pustoshilova N. N. Istomina L. R. Lebedev M. I. Svyatchenko E. D. Danilenko V. I. Masycheva S. V. Usova |
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| Affiliation: | (1) Institute of Molecular Biology, Vektor State Research Center of Virology and Biotechnology, Kol'tsovo, Novosibirsk Region;(2) Research and Technological Institute of Bioactive Agents, Vektor State Research Center of Virology and Biotechnology, Kol'tsovo, Novosibirsk Region |
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| Abstract: | Antitumor activities of tumor necrosis factor-α and its mutant analog R31Q are studied in HEp-2 and U-937 cell cultures. Cytotoxic activity of R31Q virtually does not differ from that of the initial form of tumor necrosis factor-α and its cytostatic effect was even slightly higher. The nonspecific toxicity of R31Q toward human diploid fibroblasts L-68 is lower. Comparative study of the drug pharmacokineticsin vivo showed a better preservation and higher concentration in the blood of the mutant analog of tumor necrosis factor-α. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 1, pp. 89–92, January, 1998 |
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| Keywords: | mutant tumor necrosis factor antitumor activity pharmacokinetics |
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