人类免疫缺陷病毒(HIV)感染者结核菌素试验反应的研究

目的　探讨人类免疫缺陷病毒 (HIV)感染者结核菌素试验反应状况及与免疫系统的受损程度的联系。方法 采取前瞻性病例对照研究方法，同时在病例和对照间做结核菌素试验，并对HIV抗体阳性的病例进行细胞免疫水平的测定，采用的指标有：CD₄、CD₈计数及CD₄ CD₈比值等，观察反应情况。结果 55例人类免疫缺陷病毒感染者 (HIV +)结核菌素PPD阳性反应率 (9.8%)，远比对照组 (28.2%)低得多 (P＜0.01)，反应情况与患者的细胞免疫受损程度尚待研究，但当CD₄细胞计数＜200 (艾滋病患者)时，PPD均无反应 (0×0)，当CD₄细胞计数＞300时有部分强阳性反应 (＞15mm)。结论 人类免疫缺陷病毒感染者 (HIV +)结核菌素PPD阳性反应率较常人低得多 (P＜0.01)，其PPD无反应问题尚待解决。

Study of association between immune levels and tuberculin test responses among the cases with HIV infection

Objective To investigate the tuberculin test responses among cases with HIV infection and to evaluate association between immune levels and tuberculin positive responses to cases with HIV infection in China.Methods The prospective study was applied.55 cases and 202 controls were observed.The tuberculin tests were practised among cases and controls.The levels of CD₄、CD₈、CD₄/CD₈ of HIV infections were measured by cytometry.Results The tuberculin positive rate of case group (9.8%) was significantly lower than the control group (28.2%, P＜0.01).When the count of CD₄ cell＞200(AIDS),the reaction of Tuberculin Test was 0.When the count of CD₄ cell was more than 200,the reaction of Tuberculin Tests was strong in part of cases (＞15mm).Conclusion The tuberculin positive rate of HIV infections was significantly lower than the control group ( P＜0.01).