Metoprolol in portal hypertension |
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Authors: | Priv-Doz Dr Gerd H Bützow Jochen Remmecke Andrea Bräuer |
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Institution: | (1) Medizinische Kernklinik u. Poliklinik, Univ.-Krankenhaus Eppendorf, Martinistr. 52, D-2000 Hamburg 20, Federal Republic of Germany |
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Abstract: | Summary In a controlled trial, the effect of the
1-selective blocking agent metoprolol on cirrhotic portal hypertension was investigated. A sustained reduction of portal pressure was observed in 60% of the treated patients after 1 and 2 months. No correlation between changes of portal pressure and cardiac output was established. This may indicate a direct action of-blocking substances on the splanchnic vascular system. The results suggest that treatment with metoprolol may be of value in patients with portal hypertension secondary to cirrhosis of the liver. However, to eliminate nonresponders the pressure has to be measured repeatedly. |
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Keywords: | Liver cirrhosis Portal hypertension -Blocking agents" target="_blank">gif" alt="beta" align="MIDDLE" BORDER="0">-Blocking agents |
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