Beta-secretase (BACE) and GSK-3 mRNA levels in Alzheimer's disease |
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| Authors: | Preece Paul Virley David J Costandi Moheb Coombes Robert Moss Stephen J Mudge Anne W Jazin Elena Cairns Nigel J |
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| Affiliation: | Quantuum, Departamento de Neurología, Rua das Bra?as 7-bajo-D, Mera, La Coru?a, Galicia 15177, Spain. pablo@quantuum.com |
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| Abstract: | Beta-secretase (BACE) and glycogen synthase kinase (GSK 3) are two enzymes thought to play a role in Alzheimer's disease. We extracted mRNA from 90 Alzheimer and 81 control brains. Levels of mRNA were quantified for BACE and GSK 3 with TaqMan real-time RT-PCR. We found no change in the Alzheimer's disease brains relative to controls for either the BACE or the GSK 3alpha mRNA levels. |
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