In vivo histocompatibility evaluation of polyurethane membrane modified by superfine silk-fibroin powder |
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Authors: | Chenxi Ouyang Haiye Xu Weici Wang Hongjun Yang and Weilin Xu |
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Institution: | (1) Department of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China;(2) Key Laboratory of Green Processing and Functional Textiles under Ministry of Education, Wuhan University of Science and Engineering, Wuhan, 430073, China;(3) College of Textile, Donghua University, Shanghai, 201620, China |
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Abstract: | Summary In this study, a novel polyurethane membrane, modified by superfine silk-fibroin powder, was prepared for small-diameter vascular
grafting. Scanning electron microscopy, transmission electron microscopy, and histological examination were applied to evaluate
histocompatibility of this polyurethane membrane. The polyurethane membrane was compared with polytetrafluoroethylene material.
A pseudomembrane and gap formed between polytetrafluoroethylene and the surrounding tissues, and no cells infiltrated or grew
into the polytetrafluoroethylene material. On the contrary, superfine silk-fibroin powder/polyurethane blend membrane merged
tightly with the surrounding tissues without gaps, and cells infiltrated and grew into the material. Moreover, the negative
effects of superfine silk-fibroin powder/polyurethane blend membrane on cells were less than those of its polytetrafluoroethylene
counterpart. Our findings indicated that the superfine silk-fibroin powder/polyurethane blend membrane has better histocompatibility
than polytetrafluoroethylene membrane. It is concluded that the superfine silk-fibroin powder/polyurethane blend membrane
is a promising biomaterial for small-diameter prosthesis.
This project was supported by a grant from the 973 Program of Ministry of Science and Technology of China (No. 2009CB526400). |
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Keywords: | polyurethane superfine silk-fibroin powder polytetrafluoroethylene histocompatibility |
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