Sex differences, season of birth and platelet 5-HT levels in schizophrenic patients |
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| Authors: | D. Mück-Šeler N. Pivac M. Jakovljević |
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| Affiliation: | (1) Laboratory for Molecular Neuropharmacology, Ruder Bošković Institute, Zagreb,,;(2) University Psychiatric Clinic, Clinical Hospital Centre Zagreb, and,;(3) Croatian Institute for Brain Research, Zagreb, Croatia, |
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| Abstract: | Summary. Similar occurrence of schizophrenia was observed in men and women independent of their season of birth. Platelet 5-HT concentration was determined in 116 healthy control subjects (61 male and 55 female) and 152 patients with schizophrenia (96 male and 56 female). Platelet 5-HT concentration was significantly higher in male than in female healthy persons and schizophrenic patients. Male and female healthy subjects born in different seasons had similar platelet 5-HT concentrations, whereas schizophrenic patients with different birth-seasons had significantly different platelet 5-HT concentrations. The highest platelet 5-HT levels were observed in both male and female schizophrenic patients born in winter when compared to matched healthy controls. Male schizophrenic patients born in winter had higher platelet 5-HT levels than schizophrenic men born in spring and summer. Female schizophrenic patients born in winter had higher platelet 5-HT than schizophrenic women born in all other seasons. These results indicated sex differences in platelet 5-HT levels in healthy persons and schizophrenic patients. The relationship between season of the birth and platelet 5-HT concentration observed only in schizophrenic patients added further support to the presumption that schizophrenia is connected with a disturbance in the central serotoninergic system. Received January 26, 1998; accepted September 18, 1998 |
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| Keywords: | : Platelet 5-HT male and female subjects season of birth schizophrenia healthy subjects. |
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