Rapid pain relief and remission of sternocostoclavicular hyperostosis after intravenous ibandronate therapy |
| |
Authors: | Johann D Ringe Herbert Faber Parvis Farahmand |
| |
Institution: | (1) Medizinische Klinik IV, Klinikum Leverkusen, University of Cologne, 51375 Leverkusen, Germany |
| |
Abstract: | Sternocostoclavicular hyperostosis (SCCH) is an infrequent but painful, localized disturbance of bone metabolism of unknown
etiology. The diagnosis of SCCH is generally one of exclusion, and it is therefore frequently missed or delayed, leaving patients
with pain that frequently fails to respond to standard analgesic therapy. Consequently, SCCH leads to significantly impaired
quality of life. Characteristic increased localized bone turnover and inflammatory osteitis provide a strong rationale for
using intravenous bisphosphonates to treat the condition. We report on three patients with long-standing, treatment-refractory
SCCH in whom intravenous ibandronate injections (a single administration of 4 mg followed by 2 mg every 3 months for up to
a year) produced prompt, dramatic, persistent pain relief and resolution of the other symptoms of the disease. We also review
recent evidence suggesting that SCCH is more common than generally believed and that technetium-99 bone scanning can aid in
making an accurate diagnosis. |
| |
Keywords: | ibandronate sternocostoclavicular hyperostosis intravenous injection bisphosphonate pain relief remission |
本文献已被 PubMed SpringerLink 等数据库收录! |
|