| 硫普罗宁对肝癌肝动脉化疗栓塞后肝损害的保护作用 |
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| 引用本文： | 占国清,郑三菊,朱琳,李金科,胡波,谢杏榕.硫普罗宁对肝癌肝动脉化疗栓塞后肝损害的保护作用[J].临床肝胆病杂志,2009,25(1):48-50. |
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| 作者姓名： | 占国清 郑三菊 朱琳 李金科 胡波 谢杏榕 |
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| 作者单位： | 郧阳医学院附属人民医院肝病科,湖北十堰,442000 |
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| 摘 要： | 目的探讨硫普罗宁对肝癌肝动脉化疗栓塞（TACE）后肝损害的保护作用及安全性。方法39例原发性肝癌接受TACE后肝损害的患者被随机分为两组，治疗组（25例）给予硫普罗宁0．2g每日1次静脉滴注，对照组（14例）给予葡萄糖醛酸内酯0．6g、肌苷0．4g每日1次静脉滴注。两组酌情给予其它综合治疗，疗程均为3周，观察患者治疗前后的主要临床症状、肝功能（AST、ALT、TBil）变化及药物不良反应。结果治疗组总有效率（80．0％）高于对照组（42．9％）（P〈0．05），治疗结束治疗组AST、ALT较对照组明显降低（P〈0．01），但两组TBil差异无显著性（P〉0．05）。两组均有乏力、厌食、恶心、肝区疼痛、发热、白细胞减少等TEAC术后并发症，治疗组较对照组更有效改善自觉症状。在治疗过程中治疗组出现2例皮疹。结论硫普罗宁对TACE后肝损害有较好的护肝效果及安全性。
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| 关 键 词： | 硫普罗宁 肝癌 肝动脉化疗栓塞 肝损害 |
Protective effect of tiopionin on liver injury caused by transcatheter arterial chemoembolization in liver carcinoma. |
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| ZHAN Guo-qing,ZHENG san-ju,ZHU Lin,et al..Protective effect of tiopionin on liver injury caused by transcatheter arterial chemoembolization in liver carcinoma.[J].Chinese Journal of Clinical Hepatology,2009,25(1):48-50. |
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| Authors: | ZHAN Guo-qing ZHENG san-ju ZHU Lin |
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| Institution: | Department of Hepatology;People Hospitol;Yunyang Medical College;Shiyan Hebei 442000;China |
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| Abstract: | Objective To observe the protective role and safety of tiopionin on liver injury caused by transcatheter arterial chemoembolization(TACE) in liver carcinoma.Methods 39 patients with liver carcinoma,who suffered from liver injury after TACE operation were randomly divided into two groups.The treatment group(n=25) was treated with 0.2g tiopionin once daily by intravenous drip,the control group(n=14) was given 0.6g glucurolactone and 0.4g inosine once daily by intravenous drip.The two groups were given other c... |
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| Keywords: | tiopionin liver carcinoma transarterial hepatic chemoembolization hepatic injury |
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