| Evaluation of ^99mTc Labeled Diadenosine Tetraphosphate as an Atherosclerotic Plaque Imaging Agent in Experimental Models |
| |
| 作者姓名： | 曹卫 张永学 安锐 |
| |
| 作者单位： | Department of Nuclear Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China，Department of Nuclear Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China，Department of Nuclear Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China |
| |
| 基金项目： | ThisprojectwassupportedbyagrantfromNationalNaturalSciencesFoundationofChina(No.30070310). |
| |
| 摘 要： | 99mTclabeledP1,P4di(adenosine5')tetraphos phate(Ap4A),whichcanspecificallybindtoP2purinereceptorsexpressedonatheroscleroticlesions,wasstudiedforexperimentalatheroscleroticplaquesima ginginNewZealandWhite(NZW)rabbits.1MATERIALSANDMETHODS1.1AnimalModelsNZWrabbits,weighing1.5-2.0kg,werepurchasedfromExperimentalAnimalCenterofTongjiMedicalCollege.Atheroscleroticmodelsof20maleNZWrabbitswerereplicatedbyimmuno injuryandhighcholesteroldiet1].Afterintrave nousinjectionof10%bovineseruma…
|
| 关 键 词： | 四磷酸盐 动脉粥样硬化 放射性核素 实验研究 |
| 收稿时间： | 2006-02-18 |
Evaluation of99mTc labeled diadenosine tetraphosphate as an atherosclerotic plaque imaging agent in experimental models |
| |
| Cao Wei,Zhang Yongxue,An Rui.Evaluation of ^99mTc Labeled Diadenosine Tetraphosphate as an Atherosclerotic Plaque Imaging Agent in Experimental Models[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2006,26(3):278-280. |
| |
| Authors: | Cao Wei Zhang Yongxue An Rui |
| |
| Institution: | Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China |
| |
| Abstract: | Summary The potential of99mTc labeled P1, P4-di (adenosine-5’)-tetraphosphate (Ap4A) for imaging experimental atherosclerotic plaques was evaluated in New Zealand white
(NZW) rabbits. To label the99mTc to Ap4A, stannous tartrate solution was used.99mTc-Ap4A was purified on a Sephadex G-25 column. The radiochemistry purities of99mTc-Ap4A were 85% to 91%. Biodistribution study revealed99mTc-Ap4A cleared from blood rapidly. Thirty min after99mTc-Ap4A administrated on NZW atherosclerotic rabbits, lesion to blood (target/blood, T/B) ratio was 3.17±1.27, and lesions
to normal (target/non-target, T/NT) ratio was 5.23±1.87. Shadows of atherosclerotic plaques were clearly visible on radioautographic
film. Aortas with atherosclerotic plaques also could be seen on ex vivo gamma camera images. Atherosclerotic abdominal aortas
were clearly visible on in vivo images 15 min to 3 h after99mTc-Ap4A administration.99mTc-labeled Ap4A can be used for rapid noninvasive detection of experimental atherosclerotic plaque.
Cao Wei, male, born in 1970, Doctor in Charge
This project was supported by a grant from National Natural Sciences Foundation of China (No. 30070310). |
| |
| Keywords: | technetium diadenosine tetraphosphate atherosclerotic plaque radionuclide imaging |
| 本文献已被 CNKI 万方数据 SpringerLink 等数据库收录！ |
