Gastric emptying in rats with chronic gastric fistulas |
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| Authors: | Miss Paulette E. Setler B.A. G. P. Smith M.D. |
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| Affiliation: | (1) From the Department of Physiology and Institute of Neurological Sciences, University of Pennsylvania, Philadelphia, Pa.;(2) Present address: Edward W. Bourne Behavioral Research Laboratory, Department of Psychiatry, New York Hospital-Cornell Medical Center, Westchester Division, White Plains, N. Y. |
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| Abstract: | A technic for studying gastric emptying using phenol red test meals in rats with chronic gastric fistulas was shown to yield valid and reproducible data. This method has the advantage of utilizing a chronic, unanesthetized, unrestrained animal, which may also be used to study gastric secretion. The test meal technic described here is a more sensitive detector of anticholinergic inhibition of gastric motor activity than either intragastric balloon recordings or gastric emptying methods using pellets rather than a liquid meal. |
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