Impact of young age on prognosis for head and neck cancer: a matched-pair analysis |
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Authors: | Gilroy Jeffrey S Morris Christopher G Amdur Robert J Mendenhall William M |
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Institution: | Department of Radiation Oncology, University of Florida Health Science Center, P. O. Box 100385, Gainesville, FL 32610-0385, USA. |
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Abstract: | BACKGROUND.: The purpose of this study was to review outcomes of young patients (age <40 years) treated with definitive radiotherapy alone for squamous cell carcinoma of the oropharynx, and larynx, and to compare these results with an older matched patient cohort. METHODS.: Since 1983, 30 previously untreated young patients underwent definitive radiotherapy at the University of Florida and were matched with an older group of patients (age >45 years) with respect to primary site, stage of disease, and sex. RESULTS.: There was no difference in cause-specific survival, locoregional control, or long-term complications between the two groups; however, there was a significant difference in overall survival favoring young patients (p = .0174). Older patients had twice as many second malignancies. CONCLUSION.: Young age does not confer a worse prognosis in patients treated with definitive radiotherapy for squamous cell carcinoma of the oropharynx and larynx. |
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Keywords: | young patients squamous cell carcinoma oral cavity oropharynx larynx radiotherapy treatment outcomes |
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