51例性腺外畸胎瘤的临床病理分析

目的探讨性腺外畸胎瘤临床病理特点。方法参照2003年WHO乳腺及女性生殖系统肿瘤病理学和遗传学中组织学分型对51例手术切除性腺外畸胎瘤的临床及病理特征进行回顾性分析。结果51例性腺外畸胎瘤患者发生部位多见于人体中线两旁,频率依次为纵隔、骶尾部、腹腔、盆腔、腹膜后、肺、颅内等。51例中4例为恶性,恶变率为7．8％;其中3例为成熟性畸胎瘤伴腺癌或鳞癌,1例为未成熟畸胎瘤Ⅱ级。结论性腺外畸胎瘤好发于年轻患者,多见于中线两旁,有较高的恶性率,主要表现为局部肿块及压迫症状,非体表部位畸胎瘤可合并感染,容易误诊。

51 Cases of Clinicopathological Analysis about Extragonadal Teratoma

Objective To investigate the clinicopathological characteristics of extragonadal teratoma. Methods The clinical and pathological features of 51 cases of extragonadal teratoma,which operated at Affiliated Hospital of North Sichuan Medical College during the interval from 1997 to 2011, were evaluated retrospectively according to WHO Pathology ＆ Genetics Tumors of the Breast and Female Genital Organs. Results The 51 patients with extragonadal teratoma Extragonadal teratomas occurred predominantly along the median line of the body. 12 cases were in the anterior mediastinum, 7 cases in sacrococcygeal region, 5 cases in abdominal cavity, 5 cases in pelvic cavity,4 cases in retroperitoneum space, 4 cases in lung, 4 cases in intracranial cavity. Four in 51 cases were malignant. There is a 7. 8% chance of malignancy. Three in 4 malignant teratomas mixed with squamous cell carcinoma or adenocarcinoma. 1 case was immature teratomas,Grade II. Conclusion Extragonadal teratomas tend to occur in midline structures and appear frequently in younger. Most patients typically present as an asymptomatic mass,and are usually identified only after they have grown to huge proportions. Some cases may be misdiagnosed as abscess because of infection.