On a prime role for newly synthesized dopamine in striatal function |
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Authors: | Parkhurst A. Shore Roy L. Dorris |
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Affiliation: | Department of Pharmacology, University of Texas Health Science Center, Dallas, Texas, U.S.A. |
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Abstract: | Rats were given either the tyrosine hydroxylase inhibitor, alpha-methyltyrosine (alphaMT), in doses of 10 or 250 mg/kg or the neuroleptic, haloperidol (0.25 mg/kg). Other rats received both drugs (haloperidol 30 min after alphaMT). This dose of haloperidol alone caused only a slight, gradually developing catalepsy, while alphaMT alone caused none. The combination quickly caused a strong catalepsy. Striatal dopamine (DA) stores were only minimally depleted at the time of catalepsy potentiation. Th e marked elevation of striatal homovanilluc acid concentration seen after haloperidol administration was greatly inhibited by alphaMT pretreatment. It is concluded that the marked potentiation of haloperidol-induced catalepsy by alpha MT is related to the absence of newly synthesized DA rather than to an exhausted main DA pool and that newly synthesized DA has a greater role in striatal function than does DA of the main striatal storage pool. |
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Keywords: | Homovanillic acid Catalepsy Neuroleptic Dopamine Haloperidol α-Methyltyrosine |
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