恶性胸腺瘤预后因素分析

目的:探讨影响恶性胸腺瘤患者术后生存率的相关因素。方法:分析72例恶性胸腺瘤的临床特点,运用Kaplan-Meirer法计算生存率,应用Log-rank法和COX比例风险模型对可能影响胸腺瘤术后生存率的因素进行单因素和多因素分析。结果:全组患者1、3、5年生存率为74.08%、55.60%、44.66%。单因素分析显示手术切口、大血管的累及、WHO组织学分类、Masaoka分期对恶性胸腺瘤患者术后生存率具有影响(P<0.05),多因素分析表明仅Masaoka分期、WHO组织学分类、大血管的累及是独立的预后因素。结论:恶性胸腺瘤应采用手术为主的综合治疗,Masaoka分期、WHO组织学分类、大血管的累及是影响预后的独立因素。

The Analysis of Prognostic Factors for Patients with Malignant Thymoma

Objective: To explore the prognostic factors affecting the survival of patients with malignant thymoma. Methods: A total of 72 patients with malignant thymoma surgically treated from June 1994 to June 2003 were studied retrospectively. The possible prognostic factors were analyzed by univariate analysis and multi-variate analysis with Kaplan-Meier, Log-rank and Cox proportional hazard model. Results: Overall patients survival rates were 74.08%、55.60%、44.66% at 1, 3, 5 years, respectively. The significant prognostic factors demonstrated by univariate analysis included incision, invasion of great blood vessels, Masaoka staging and WHO histologic classification (P<0.05). According to multivariate analysis, the independent prognostic factors were invasion of great blood vessels, Masaoka staging and WHO histologic classification. Conclusion: Surgical resection is the effective treatment of malignant thymoma. Howerer, innvasion of great blood vessels, Masaoka staging and WHO histologic classification are the independent pognostic factors of those patients.