中国城市3~12岁儿童IgE介导的食物过敏研究

目的了解中国城市儿童Ig E介导的食物过敏状况,包括食物过敏发生率和主要过敏原种类的调查。方法从中国居民营养与健康状况调查血清库根据不同年龄段和性别挑选3~12岁儿童血清样本,采用酶联免疫法测定样本的总Ig E,采用免疫印迹法对总Ig E阳性的样本进行特异性Ig E检测。结果共测定5190例血清样本,通过检测特异性Ig E获得Ig E介导的食物过敏率为3.20%,大城市食物过敏率为2.70%,中小城市食物过敏率为3.77%;随着年龄的增长食物过敏率逐渐下降,不同性别之间差异无统计学意义。最主要的食物过敏原为牛奶、鸡蛋白,其次为牛肉、坚果类。结论采用测定血清总Ig E和特异性Ig E,可初步对儿童过敏情况及主要引起过敏的食物种类进行筛查分析。

Study on Ig E mediated food allergy of 3-12 years urban children in China

Objective To study the situation of IgE-mediated food allergy of Chinese urban children,including the rate of food allergy and the main food allergens in children.Methods All the serum samples were selected from the serum bank built by the national nutrition and health survey of Chinese residents. Total IgE of all the samples were tested by enzyme linked immunosorbent assay,and the s IgE of T IgE-positive samples were then tested by immunoblotting. Results A total of 5190 samples were selected from serum bank,and the rate of Ig E-mediated food allergy was 3. 20%. The rate of IgE-mediated food allergy was 2. 70% in big cities,while it was 3. 77% in small and medium-sized cities. The rate was gradually decreased with age grown. Conclusion The situation of food allergy in children and the main allergens could be preliminary determined by testing the serum total Ig E level and specific IgE.