肿瘤标志物CEA、NSE、CA211和SCC在肺癌诊断中的临床意义

目的 探讨血清肿瘤标志物(TMs)癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、糖原211(CA211)、鳞状细胞相关抗原(SCC)联合检测在肺癌诊断中的价值.方法 应用化学发光免疫法检测103例肺癌组、30例肺部良性肿块组和50例正常对照组患者血清中CEA、NSE、CA211和SCC 4种TMs的浓度.结果 肺癌组与良性肿块组和健康对照组中的4种TMs含量比较均有统计学意义(P<0.05),良性肿块组与健康对照组比较均无统计学意义(P>0.05).CEA在肺腺癌中表达阳性率明显增高;SCC、CA211在肺鳞癌和腺癌中表达阳性率明显增高;NSE在小细胞肺癌中表达阳性率明显增高.CEA+CA211+NSE组合用于检测肺癌时的阳性率明显高于其他组合.结论 血清CEA、NSE、CA211和SCC在肺癌诊断中具有重要意义,CEA+CA211+NSE组合联合检测诊断不同病理分型的肺癌阳性率最高.

Clinical Significance of CEA, NSC, CA211 and SCC in the Diagnosis of Lung Cancer

ObjectiveTo evaluate the clinical value of combined detection of serum carcinoembryonic antigen (CEA), neuro-specific enolase (NSE), carbohydrate antigen 211 (CA211) and squamous cell carcinoma associated antigen (SCC) in patients with lung cancer. MethodsThe CEA, NSE, CA211 and SCC contents were detected in 103 lung cancer patients, 30 benign lung mass patients and 50 controls by chemiluminescence immunoassay. ResultsThe concentrations of the four tumor markers in lung cancer group were significantly different from those in benign lung mass group and control group (P<0.05), but in benign lung mass group they were same as those in control group (P>0.05). The positive expression rate of CEA increased significantly in lung adenocarcinoma,and SCC and CA211 in lung squamous cell carcinoma and lung adenocarcinoma, while NSE in small cell lung cancer. The positive percentage of the combination of CEA+CA211+NSE in lung cancer was higher than the other combinations. ConclusionSerum CEA, NSE, CA211 and SCC are helpful for the diagnosis of lung cancer, and the positive percentage of the combination of CEA+CA211+NSE in lung cancer was the highest level.