口服华法林患者血浆蛋白质Z水平检测的临床意义

目的:观察口服华法林患者血浆蛋白质Z(protein Z,PZ)含量的变化,并探讨其变化发生的原因以及对华法林口服量的监测作用。方法:30例口服华法林患者为一组,23名正常人为对照组,分别进行PZ、血浆凝血酶原时间(prothrombin time,PT)、PT国际标准化比值(PT:INR)测定。PZ用ELISA法检测,PT和PT:INR用全自动血凝仪测定。结果:口服华法林组PZ为(240.87±192.72)ng/ml,明显低于对照组(1 812.6±347.16)ng/ml(P<0.001)。口服华法林组PT为(24.18±4.52)s,明显高于对照组(12.67±0.42)s(P<0.001)。口服华法林组PT:INR值(2.448±0.63)亦明显高于对照组(0.943±0.04)(P<0.001)。结论:口服华法林患者PZ水平明显减低,提示口服华法林可能导致蛋白质Z的缺乏,血浆蛋白质Z水平可作为华法林口服量的一项监测指标。

Clinical significance of plasma protein Z level in patients with taking orally warfarin

Objective：To observe the alteration of protein Z（PZ） in patients with taking orally warfarin. Research the reason of this alteration and the monitor function of the PZ in patients with taking orally warfarin. Methods：Thirty patients with taking orally warfarin and 23 healthy adults as the control group,and detect the level of the plasma PZ and prothrombin time （PT）, PT： INR. PZ was measured by ELISA and PT, PT： INR were measured by stago auto-analyor. Results：In taking orally warfarin group PZ levels was （240.87 ± 192.72）ng/ml. It compared with health group＇s PZ level （1 812.6 ± 347, 16）ng/ml has dropped （P 〈 0. 001 ）. Taking orally warfarin group＇s PT（ 24.18 ± 4.52 ）s compared with health group＇s PT（ 12.67 ± 0. 42 ）s has raised （P 〈 0. 001 ）. Taking orally warfarin group＇s PT： INR （2. 448 ± 0.63 ） compared with health group＇ s PT： INR （0. 943 ± 0.04 ） has raised （P 〈 0. 001 ）. Conclusions：PZ level of the patients who take orally warfarin is obrions drop. Fingdings shows that taking orally warfarin could make the PZ drop. The plasma protein Z level can be used as an indicator to monitor the amonnt of warfarin.