| 慢性不可预见性应激对大鼠大脑皮质及海马酪氨酸硝基化的影响 |
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| 引用本文： | 吕保来,吴爱群,曹莉,周强,何成.慢性不可预见性应激对大鼠大脑皮质及海马酪氨酸硝基化的影响[J].解剖学杂志,2006,29(4):473-475,F0003. |
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| 作者姓名： | 吕保来 吴爱群 曹莉 周强 何成 |
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| 作者单位： | 第二军医大学神经生物学教研室,上海,200433;郑州大学解剖学教研室,郑州,456000;第二军医大学人体解剖学教研室,上海,200433;第二军医大学神经生物学教研室,上海,200433;郑州大学解剖学教研室,郑州,456000 |
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| 基金项目： | 国家重点基础研究发展计划(973计划);国家自然科学基金;上海市青年科技启明星计划;上海市科技发展基金 |
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| 摘 要： | 目的：探讨慢性应激能否使SD大鼠大脑皮质神经细胞产生蛋白质酪氨酸硝基化。方法：将40只SD大鼠随机分为对照组和慢性不可预见性应激组各20只,用慢性不可预见性应激模型法造模,时间分为1周、2周和3周,每周用Open-field法给予行为学评分,并用组织化学和免疫组织化学法染色观察大脑神经细胞形态和其蛋白质酪氨酸硝基化的变化。结果：慢性不可预见性应激组与对照组神经细胞形态有明显的不同,且出现蛋白质酪氨酸硝基化,两组相比具有显著统计学意义。结论：慢性不可预见性应激模型鼠的大脑皮质神经细胞发生慢性应激损伤,是有效的慢性应激模型,其发生机制至少部分与NO~ 的产生而导致神经细胞蛋白质酪氨酸硝基化有关。
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| 关 键 词： | 应激 大脑皮质 海马 酪氨酸 |
| 收稿时间： | 2005-11-12 |
| 修稿时间： | 2005-11-122006-01-23 |
Influence of chronic unpredictable stress on nitrotyrosine in hippocampus and parietal cortex of rats |
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| L Bao-Lai,WU Ai-Qun,CAO Li,ZHOU Qiang,HE Cheng.Influence of chronic unpredictable stress on nitrotyrosine in hippocampus and parietal cortex of rats[J].Chinese Journal of Anatomy,2006,29(4):473-475,F0003. |
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| Authors: | L Bao-Lai WU Ai-Qun CAO Li ZHOU Qiang HE Cheng |
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| Institution: | 1. Department of Neurobiology, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China; 2. Department of Anatomy, College of Basic Medical Science, Zhengzhou University. Zhengzhou 456000, China; 3. Department of Anatomy, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China |
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| Abstract: | Objective:Tu explore whether chronic stress can induce nitrotyrosine in rat hippocampus and cortex. Methods:Forty rats were evenly divided into 2 groups:control group and chronic stress group (1 week,2 weeks and 3 weeks).Nirotyrosine in parietal cortex and hippocampus were observed and analyzed with immunohisto- chemical method.Results:Nitrotyrosine was detected in parietal cortex and hippocampus in chronic stress group, but not in control group.Conclusion:These findings indicate that protein tyrosine nitration may be responsible, at least in part,for some of neurodegenerative changes caused by chronic stress. |
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| Keywords: | stress cerebral cortex hippocampus tyrosine |
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