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| 黄花乌头茎叶中一个新的Hetisine型生物碱 | |
| 引用本文： | 汤庆发,杨春华,刘静涵,叶文才,赵守训,吕扬,冒莉,郑启泰.黄花乌头茎叶中一个新的Hetisine型生物碱[J].药学学报,2005,40(7):640-643. |
| 作者姓名： | 汤庆发 杨春华 刘静涵 叶文才 赵守训 吕扬 冒莉 郑启泰 |
| 作者单位： | 1. 中国药科大学天然药物化学教研室,江苏,南京,210009 2. 中国药科大学分析测试中心,江苏,南京,210009 3. 中国药科大学天然药物化学教研室,江苏,南京,210009;暨南大学,中药及天然药物研究所,广东,广州,510632 4. 中国医学科学院、中国协和医科大学,药物研究所,北京,100050 |
| 基金项目： | 国家高技术研究发展计划(863计划)资助项目(2002AA223102). |
| 摘 要： | 目的研究黄花乌头茎叶的化学成分。方法采用现代色谱方法进行化学成分分离，并通过各种波谱学分析鉴定化合物的结构。结果从黄花乌头茎叶中分离得到2个化合物，分别鉴定为13-dehydro-1β-acetyl-2α,6β-dihydroxyhetisine (I)和关附庚素(II)。结论I为新化合物。 |
| 关 键 词： | 黄花乌头 Hetisine型生物碱 关附午素 |
| 收稿时间： | 2004-10-09 |
A new hetisine-type alkaloid from the stems and leaves of Aconitum coreanum |
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| TANG Qing-fa,YANG Chun-hua,LIU Jing-han,YE Wen-cai,ZHAO Shou-xun,L Yang,MAO Li,ZHENG Qi-Tai.A new hetisine-type alkaloid from the stems and leaves of Aconitum coreanum[J].Acta Pharmaceutica Sinica,2005,40(7):640-643. | |
| Authors: | TANG Qing-fa YANG Chun-hua LIU Jing-han YE Wen-cai ZHAO Shou-xun L Yang MAO Li ZHENG Qi-Tai |
| Institution: | Department of Phytochemistry, China Pharmaceutical University, Nanjing 210009, China. |
| Abstract: | AIM: To study the chemical constituents of the stems and leaves of Aconitum coreanum (Lèvl.) Rapaics. METHODS: The constituents of Aconitum coreanum were isolated by using various kinds of modern chromatographic methods. The new alkaloid was identified on the basis of spectral analysis. RESULTS: Two compounds were isolated and identified as: 13-dehydro-1beta-acetyl-2alpha,6beta-dihydroxyhetisine (I) and Guanfu base G (II). CONCLUSION: Compound I is a new alkaloid. |
| Keywords: | hetisine-type alkaloid 13-dehydro-1β-acetyl-2α 6β-dihydroxyhetisine Aconitum coreanum |
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