Effect of cinoxacin on cellular metabolism and p-aminohippurate transport in kidney cortical slices in terms of its nephrotoxic action |
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| Authors: | M Gemba T Komamura Y Matsushima T Itoh K Miyata M Nakamura |
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| Institution: | 1. Department of Pharmacology, Osaka College of Pharmacy, Kawai, Matsubara, Osaka 580, Japan;1. Shionogi Research Laboratories, Shionogi and Co., Ltd., Fukushima-ku, Osaka 553 Japan |
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| Abstract: | Cinoxacin is a drug which, at very high doses, causes renal damage only in rats. This study compared the in vitro effects of cinoxacin and nalidixic acid on cellular metabolism and p-aminohippurate (PAH) transport in renal cortical slices. Cinoxacin had no effect on Na+ transport, ATP content, oxygen consumption, inulin space and tissue water content, in rat renal cortical slices in vitro, while nalidixic acid affected most of the parameters tested. PAH uptake by slices from rats pre-treated with a nephrotoxic dose of cinoxacin was decreased. This renal damage appeared to be due to physical trauma resulting from deposition of cinoxacin crystals in the urinary tract. |
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| Keywords: | Nalidixic acid ATP content oxygen consumption inulin space tissue water content renal damage PAH To whom correspondence should be addressed |
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