寻常型银屑病皮损中血管紧张素Ⅱ及血管紧张素转化酶的检测

目的:检测寻常型银屑病皮损中血管紧张素Ⅱ(AngⅡ)及血管紧张素转化酶(ACE)的水平变化。方法:应用荧光定量聚合酶链反应(FQ-PCR)和免疫组化技术检测30例寻常型银屑病患者(进行期17例,静止期13例)皮损AngⅡ和ACE mRNA及蛋白质的表达。结果:银屑病患者皮损中AngⅡ和ACE mRNA及蛋白质的表达明显高于正常人对照组(P0.001),且进行期高于静止期(P0.001)。结论:AngⅡ和ACE在银屑病皮损中表达上调,推测可能与银屑病皮损中新血管的形成有关。

The expression of angiotensin II and angiotensin converting enzyme in patients with psoriasis

Objective： To detect the level of angiotensin II （Ang II） and angiotensin converting enzyme （ ACE） in patients with psoriasis vulgaris. Methods：The level of Ang II and ACE was detected by fluorescent quantitative polymerase chain reaction （ FQ-PCR） and immunohistochemistry technique in 30 patients with psoriasis vulgaris （ progressing stage in 17 cases and stable stage in 13） and 15 normal controls. Results：The level of Ang II and ACE protein was significantly higher in psoriatic lesions than in controls （ P〈0.001） and in progressing stage higher than in stable stage （ P〈0.001） . Conclusion：Over expression of Ang II and ACE in psoriatic lesions may be implicated in the neovascularization of psoriasis.