| 载脂蛋白E基因多态性与冠心病的关系 |
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| 引用本文： | 张少敏,崔彦. 载脂蛋白E基因多态性与冠心病的关系[J]. 中国实用内科杂志, 2001, 21(1): 18-20 |
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| 作者姓名： | 张少敏 崔彦 |
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| 作者单位： | 深圳市孙逸仙心血管医院内科, |
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| 摘 要： | 目的研究载脂蛋白E(ApoE)基因多态性与冠心病发病及对血脂代谢影响的关系。方法对71例冠心病患者(CHD组)和69例正常对照者(对照组)的静脉全血白细胞提取DNA，应用PCR,HhaI酶切，用12％聚丙烯酰胺凝胶电泳，检测出其ApoE基因型及等位基因分布频率。结果CHD组及对照组均检出4种基因型，分别是E
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| 关 键 词： | 载脂蛋白E基因多态性冠心病 |
| 文章编号： | 1005-2194(2001)01-0018-03 |
| 修稿时间： | 2000-04-06 |
Relationship betweenapolipoprotein E polymorphism and coronary heart disease |
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| ZHANG Shaomin,Cui Yan. Relationship betweenapolipoprotein E polymorphism and coronary heart disease[J]. Chinese Journal of Practical Internal Medicine, 2001, 21(1): 18-20 |
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| Authors: | ZHANG Shaomin Cui Yan |
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| Affiliation: | Zhang Shaomin,Cui Yan Sun Yat-sen Cardiovascular Hospital of Shenzhen,Shenzhen 518001,China |
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| Abstract: | Objective To study the effect of apolipoprotein E (ApoE) polymorphism on serum lipids and the relationship between apolipoprotein E polymorphism and coronary heart disease (CHD).Methods Polymerize chain reaction (PCR) and HhaI digestion were used for the detection of apolipoprotein E genotype on 71 patients with CHD and 69 control subjects.Results The frequencies of apolipoprotein E4 allele and E3/4 genotype were obviously increased in CHD group than in control group (P<0.01,P<0.05). Conclusion The apolipoprotein E polymorphism is related to the occurrence of coronary heart disease; apolipoprotein E4 allele is one of the most important hereditary factor for the occurrence of CHD. |
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| Keywords: | Apolipoprotein E Gene Polymorphism Coronary heart disea |
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