| COX-2、Survivin在子宫内膜癌中的表达及意义 |
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| 引用本文： | 杨秋云,赵敬河,侯淑英,刘威.COX-2、Survivin在子宫内膜癌中的表达及意义[J].航空航天医药,2011,22(5):544-545. |
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| 作者姓名： | 杨秋云 赵敬河 侯淑英 刘威 |
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| 作者单位： | 哈尔滨医科大学附属第五医院妇产科,大庆,163316 |
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| 基金项目： | 黑龙江省卫生厅资助项目 |
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| 摘 要： | 目的：探讨环氧化酶-2（COX-2）和Survivin在子宫内膜癌发生发展中的作用。方法：采用免疫组化SP法检测39例子宫内膜癌和14例正常子宫内膜组织中COX-2、Survivin的表达。结果：子宫内膜癌组织中COX-2、Survivin的阳性表达率明显高于正常子宫内膜组织（P〈0.05）;低分化和肌层浸润〉1/2者的子宫内膜癌组织中COX-2、Survivin表达明显高于中、高分化和肌层浸润≤1/2（P〈0.05）者;子宫内膜癌组织中COX-2表达与临床分期无关。子宫内膜癌组织中Survivin表达与临床分期相关。COX-2表达阳性的子宫内膜癌,其Survivin阳性率明显高于COX-2表达阴性者（P〈0.05）。结论：COX-2、Survivin在子宫内膜癌组织中呈高表达,呈现一致性。二者可能与子宫内膜癌的发生发展有关。
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| 关 键 词： | 子宫内膜癌 COX-2 Survivin |
Effect of Cyclooxygenase-2 and Survivinin in Endometrial Carcinoma |
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| YANG Qiu-yun,ZHAO Jing-he,HOU Shu-ying,et al..Effect of Cyclooxygenase-2 and Survivinin in Endometrial Carcinoma[J].Aerospace Medicine,2011,22(5):544-545. |
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| Authors: | YANG Qiu-yun ZHAO Jing-he HOU Shu-ying |
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| Institution: | YANG Qiu-yun,ZHAO Jing-he,HOU Shu-ying,et al.(The Affiliated Fifth Hospital of Harbin Medical University,Daqing 163316,China) |
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| Abstract: | Objective:To investigate the effect of cyclooxygenase-2(COX-2)and Survivinin in endometrial carcinoma.Methods:The expression of COX-2 and Survivin were examined by immunohistochemistry SP method in 39 cases of endometrial carcinoma and 14 cases of normal endometrium.Results:The expression of COX-2 and Survivin was significantly higher in endometrial carcinoma than in normalendometrium(P<0.05).Over expression of COX-2 and Survivin in endometrial carcinoma was related to differentiation degree and depth of in... |
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| Keywords: | COX-2 Survivin |
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