经络舒胶囊对糖尿病大鼠活血化瘀及抗炎镇痛作用

目的:观察经络舒胶囊对糖尿病大鼠的活血化瘀、抗炎镇痛作用。方法:经络舒胶囊药粉每次给药高、中、低剂量组(大鼠为1.4,0.7,0.35 g·kg-1;小鼠为2.8,1.4,0.7 g·kg-1),阳性药糖脉康颗粒剂量为2.5 g·kg-1,每天ig给药1次。Wistar大鼠ip链脲佐菌素(STZ)制成糖尿病大鼠模型,将动物随机分为正常对照组、模型对照组、西药阳性对照组、中药阳性对照组、经络舒胶囊高、中、低剂量组i,g连续60 d进行高、中、低切变率的全血比黏度测定;以正常大鼠组胺所致的大鼠毛细血管通透性增加及棉球肉芽肿形成检测抗炎作用;以热板法和醋酸致小鼠扭体法检测镇痛作用。结果:经络舒胶囊能明显降低糖尿病大鼠血液全血的高、中、低切变率的全血比黏度,对组胺所致的大鼠毛细血管通透性增加无明显的抑制作用;对棉球肉芽肿的形成有明显的抑制作用;给药后30,60 min均能延长热板法小鼠痛阈值;能明显减少醋酸致小鼠扭体次数。结论:经络舒胶囊对糖尿病大鼠具有明显的活血化瘀、抗炎、镇痛作用。

Effect of Jingluoshu Capsule for Activating Blood Circulation to Remove Blood Stasis,its Action of Anti-inflammation and Analgesic in Diabetic Rats

Objective: To investigate the effect of Jingluoshu Capsule for activating blood circulation to remove blood stasis (ABCRBS),and its analgestic and anti-inflammatory action in diabetic rats. Method: High,medium and low dose groups of Jingluoshu Capsule,1.4,0.7,0.35 g ·kg^-1in rats and 2.8,1.4,0.7 g ·kg^-1in mice accordingly,were established.,Positive medicine (Tangmaikang Grannules) was ig given once daily at the dose of 2.5 g ·kg^-1.The diabetic rat model was established by intraperitoneal injection of streptozotocin (STZ) in Wistar rats.The animals were randomly divided into normal control group,model control group,positive medicine control group,positive control group of Chinese medicine,high,medium and low dose groups of.Jingluoshu Capsule.of the efficacy of the drugs was evaluated with hemorrheological parameters,anti-inflammation and analgestic tests. Result: Jingluoshu Capsule could decrease the whole blood viscosity at high shear rate,show inhibitory action on the increase in capillary permeability induced by histamine.The capsule significantly inhibited the formation of granuloma induced with cotton ball.After 30 and 60 minutes of administration,it could prolong the time of first licking feet in the hot-plate test in mice and increase the pain threshold.The capsule could also significantly decrease the number of twisting body induced by acetic acid in mice,showing a significant analgesic effect. Conclusion: Jingluoshu Capsule has significant effect of activating blood circulation to remove blood stasis,and anti-inflammatory,analgestic actions in diabetic rats.