| 康脑液2号对局灶性脑缺血再灌注大鼠的治疗作用及其机制 |
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| 引用本文： | 梁起保,薛茜,赵秀芳,石会娟,邹玉安.康脑液2号对局灶性脑缺血再灌注大鼠的治疗作用及其机制[J].中国老年学杂志,2011,31(10). |
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| 作者姓名： | 梁起保 薛茜 赵秀芳 石会娟 邹玉安 |
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| 作者单位： | 1. 河北北方学院,河北,张家口,075000
2. 河北北方学院附属第一医院 |
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| 基金项目： | 河北省卫生厅课题资助项目 |
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| 摘 要： | 目的 观察康脑液2号对局灶性脑缺血再灌注(I/R)大鼠的治疗作用.方法 150只雄性SD大鼠随机分为假手术组、模型组,康脑液2号高、中、低剂量组.线栓法制备大鼠右侧大脑中动脉闭塞(MCAO)模型.大鼠缺血2 h,于再灌注24 h后观察神经功能,再灌注1、3、7,14,21 d,HE染色观察病理变化,免疫组织化学法观察各组大鼠血管内皮生长因子(VEGF)、血管生成素-1(Ang-1)表达,再灌注21 d免疫组织化学法标记CD105检测血管密度.结果 与模型组相比,康脑液2号治疗组神经功能及病理改变明显改善.各种促血管生成因子明显多于模型组(P<0.05或P<0.01),脑组织血管显著增多(P<0.05或P<0.01).结论 康脑液2号能治疗脑I/R大鼠,可能促进脑I/R大鼠缺血周围区域血管新生.
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| 关 键 词： | 康脑液2号 缺血再灌注 血管新生 血管密度 |
Effects of No.2 kangnao liquid on treating rats with focal cerebral ischemia reperfusion injury and its mechanisms |
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| LIANG Qi-Bao,XUE Qian,ZHAO Xiu-Fang,et al..Effects of No.2 kangnao liquid on treating rats with focal cerebral ischemia reperfusion injury and its mechanisms[J].Chinese Journal of Gerontology,2011,31(10). |
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| Authors: | LIANG Qi-Bao XUE Qian ZHAO Xiu-Fang |
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| Institution: | LIANG Qi-Bao,XUE Qian,ZHAO Xiu-Fang,et al.Hebei north university,Zhangjiakou 075000,Hebei,China |
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| Abstract: | Objective To investigate the effects of No.2 kangnao liquid on rats with focal cerebral ischemia-reperfusion(I/R).Methods 150 healthy male SD rats were randomly divided into 5 groups:sham operated,model,high-,middle-and low-dose No.2 kangnao liquid groups.The animal models of middle cerebral artery occlusion(MCAO) were established by a monofilament method from right external-internal carotid artery.Neurological evaluation was performed 24 h after reperfusion,and immunohistochemical techniques were employed ... |
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| Keywords: | No 2 kangnao liquid Cerebral ischemia reperfusion injury Angiogenesis |
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