| 菝葜中的甾体皂苷及其细胞毒活性 |
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| 引用本文： | 徐燕,王海燕,蒋家月,项威,李曼曼,梁敬钰. 菝葜中的甾体皂苷及其细胞毒活性[J]. 中国实验方剂学杂志, 2011, 17(11): 92-96 |
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| 作者姓名： | 徐燕 王海燕 蒋家月 项威 李曼曼 梁敬钰 |
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| 作者单位： | 1. 安徽农业大学安徽省食品与安全重点实验室,合肥,230036
2. 中国药科大学天然药化教研室,南京,210009 |
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| 摘 要： | 目的:研究菝葜Smilax china L.的甾体皂苷类成分及其细胞毒活性。方法:利用色谱技术进行分离纯化,并根据化合物的理化性质和光谱数据进行结构鉴定。采用MTT法对分离得到的单体化合物进行细胞毒活性的初筛。结果:从该植物乙醇提取物的正丁醇部分分离得到6个甾体皂苷,分别鉴定为borassoside B(1),薯蓣皂苷(2),原薯蓣皂苷(3),22-O-甲基原薯蓣皂苷(4),isonarthogenin 3-O-α-L-rhamnopyranosyl(1-2)-O-[α-L-rhamnopyranosyl-(1-4)]-β-D-glucopyranoside(5),diosgenin-3-O-[α-L-rha(1-3)-α-L-rha(1-4)-α-L-rha(1-4)]-β-D-glucopyranoside(6)。在样品溶液质量浓度为5 mg.L-1时,化合物2和6对K-562癌细胞生长的抑制率分别是89.1%9,0.1%。结论:化合物1和6是首次从该植物中分离得到,也是首次从菝葜属植物中分离得到。化合物2和6对K-562癌细胞具有明显的体外细胞毒活性。
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| 关 键 词： | 菝葜 化学成分 甾体皂苷 细胞毒活性 |
| 收稿时间： | 2011-01-30 |
Studies on Steroidal Saponins from Smilax china and Their Cytotoxic Activities |
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| XU Yan,WANG Hai-yan,JIANG Jia-yue,XIANG Wei,LI Man-man and LIANG Jing-yu. Studies on Steroidal Saponins from Smilax china and Their Cytotoxic Activities[J]. China Journal of Experimental Traditional Medical Formulae, 2011, 17(11): 92-96 |
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| Authors: | XU Yan WANG Hai-yan JIANG Jia-yue XIANG Wei LI Man-man LIANG Jing-yu |
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| Affiliation: | Key Laboratory of Food Quality and Safety of Anhui Province, Anhui Agricultural University, Hefei 230036, China;Key Laboratory of Food Quality and Safety of Anhui Province, Anhui Agricultural University, Hefei 230036, China;Key Laboratory of Food Quality and Safety of Anhui Province, Anhui Agricultural University, Hefei 230036, China;Key Laboratory of Food Quality and Safety of Anhui Province, Anhui Agricultural University, Hefei 230036, China;Key Laboratory of Food Quality and Safety of Anhui Province, Anhui Agricultural University, Hefei 230036, China;Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | |
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| Keywords: | Smilax china chemical constituents steroidal saponins cytotoxic activities |
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