| 五灵肩周丸镇痛抗炎作用和急性毒性研究 |
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| 引用本文： | 刘霭明,孔焕育,石光,罗超,曹莹,谢宝平,庞建新,丘玉昌. 五灵肩周丸镇痛抗炎作用和急性毒性研究[J]. 中国实验方剂学杂志, 2011, 17(11): 202-204 |
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| 作者姓名： | 刘霭明 孔焕育 石光 罗超 曹莹 谢宝平 庞建新 丘玉昌 |
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| 作者单位： | 南方医科大学药学院新药评价中心,广州,510515 |
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| 摘 要： | 目的:研究五灵肩周丸的镇痛抗炎作用及急性毒性。方法:采用小鼠扭体实验和甲醛致痛模型来观察五灵肩周丸的镇痛作用;抗炎实验采用大鼠棉球肉芽肿实验及小鼠二甲苯致耳廓肿胀模型;采用小鼠单次ig的方法测定其LD50。结果:给予3.8,7.6 g·kg-1的五灵肩周丸能明显减少醋酸所致小鼠的扭体次数(P<0.05),抑制二甲苯引起的小鼠耳肿胀(P<0.01);五灵肩周丸在3.8,11.4 g·kg-1时能明显减轻甲醛致痛实验中小鼠的Ⅰ相疼痛反应(P<0.01),但对甲醛引起的Ⅱ相疼痛反应没有显著影响;剂量为7.6 g·kg-1时对大鼠棉球肉芽肿的形成有明显的抑制作用(P<0.05);急性毒性试验表明,其LD50为148.4 g·kg-1。结论:五灵肩周丸具有明显的镇痛抗炎作用,且具有较高的安全性。
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| 关 键 词： | 五灵肩周丸 镇痛 抗炎 急性毒性 |
| 收稿时间： | 2011-01-13 |
Analgesic and Anti-inflammatory Effects and Acute Toxicity of Wuling Jianzhou Pellet |
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| LIU Ai-ming,KONG Huan-yu,SHI Guang,LUO Chao,CAO Ying,XIE Bao-ping,PANG Jian-xin and QIU Yu-chang. Analgesic and Anti-inflammatory Effects and Acute Toxicity of Wuling Jianzhou Pellet[J]. China Journal of Experimental Traditional Medical Formulae, 2011, 17(11): 202-204 |
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| Authors: | LIU Ai-ming KONG Huan-yu SHI Guang LUO Chao CAO Ying XIE Bao-ping PANG Jian-xin QIU Yu-chang |
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| Affiliation: | Center for Preclinical Evaluation of New Drugs,School of Pharmaceutical Sciences, Southern Medical University,Guangzhou 510515,China;Center for Preclinical Evaluation of New Drugs,School of Pharmaceutical Sciences, Southern Medical University,Guangzhou 510515,China;Center for Preclinical Evaluation of New Drugs,School of Pharmaceutical Sciences, Southern Medical University,Guangzhou 510515,China;Center for Preclinical Evaluation of New Drugs,School of Pharmaceutical Sciences, Southern Medical University,Guangzhou 510515,China;Center for Preclinical Evaluation of New Drugs,School of Pharmaceutical Sciences, Southern Medical University,Guangzhou 510515,China;Center for Preclinical Evaluation of New Drugs,School of Pharmaceutical Sciences, Southern Medical University,Guangzhou 510515,China;Center for Preclinical Evaluation of New Drugs,School of Pharmaceutical Sciences, Southern Medical University,Guangzhou 510515,China;Center for Preclinical Evaluation of New Drugs,School of Pharmaceutical Sciences, Southern Medical University,Guangzhou 510515,China |
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| Abstract: | |
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| Keywords: | Wuling Jianzhou pellet analgesic anti-inflammatory acute toxicity |
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