广州地区新生儿G6PD缺乏的早期诊断及其防治

「目的」对新生儿筛查的检出的Ｇ６ＰＤ缺陷与高胆的关系进行临床研究，探讨Ｇ６ＰＤ缺陷的早期诊断及其高胆的防治方法。「方法」用荧光斑点法对新生儿进行Ｇ６ＰＤ缺陷定性筛查，阳性病例用Ｇ６ＰＤ／６ＰＧＤ比值法进一步确诊，临床观察本组８０例Ｇ６ＰＤ缺陷的高胆病程。「结果」本组Ｇ６ＰＤ缺陷新生儿５０％发生了高胆；高胆９０％于生后２￣３天起病；重度高胆占２５％，仅见于重度Ｇ６ＰＤ缺陷者；轻－中缺陷者高胆程度轻；

Early Diagnosis of G6PD Deficiency and Its Prophylaxis and Treatment in Guangzhou

Objective To study the methods for early diagnosis of G6PD deficiency and prevention of hyperbilirubinemia(HB). Methods With dry blood spot on the screening paper G6PD activity was measured.G6PD/6PGD ratio test of the venous blood sample was further performed for confirmation.The relationship between G6PD deficiency and HB was analyzed. Results 50% of the 80 cases in this G6PD deficiency group took place HB.Jaundice was observed on 2 3 day after birth in 90% of the HB cases. 27.5% of the HB cases were severe type. The more deficient of the G6PD activity the more severe of the HB.The other factors included using oxytocin at the birth,perinatal infection and premature would induce and accentuate HB. Conclusions It is very important to diagnose G6PD dificiency and protect from HB early,because its high incidence,early onset,severe degree were harmful to the newborn.Screening with cord blood using fluorescent spot test may be the one of the important way to diagnose G6PD deficiency at the early stage.The methods to protect from HB included taking luminal,vitaminE by the gestational women at the prenatal stage,avoiding the factors which easy to induce HB at the delivery period,and give the newborn vitaminE,luminal and light therapy early.