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The Rotterdam Study: 2010 objectives and design update
Authors:Albert Hofman  Monique M B Breteler  Cornelia M van Duijn  Harry L A Janssen  Gabriel P Krestin  Ernst J Kuipers  Bruno H Ch Stricker  Henning Tiemeier  André G Uitterlinden  Johannes R Vingerling  Jacqueline C M Witteman
Institution:1. Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
2. Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
3. Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands
4. Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands
Abstract:The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. The findings of the Rotterdam Study have been presented in close to a 1,000 research articles and reports (see www.epib.nl/rotterdamstudy). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods.
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