Prevalence of hepatitis B and C serological markers among first-time blood donors in Brazil: a multi-center serosurvey |
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Authors: | Nascimento Maria Claudia Mayaud Philippe Sabino Ester Cerdeira Torres Katia Luz Franceschi Silvia |
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Affiliation: | 1. Laboratório de Virologia do Instituto de Medicina Tropical, Departamento de Moléstias Infecciosas e Parasitárias da Faculdade de Medicina, Universidade de S?o Paulo, Sao Paulo, Brazil;2. International Agency for Research on Cancer, Lyon, France;3. Clinical Research Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom;4. Pro‐blood Foundation, Blood Center of S?o Paulo, Sao Paulo, Brazil;5. Funda??o de Hematologia e Hemoterapia do Amazonas, Manaus, Brazil |
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Abstract: | Little data are available on the seroprevalence of, and risk factors for hepatitis B and C viruses (HBV and HCV) infection in Latin American countries. A multi-center serosurvey was conducted among 3,598 first-time blood donors (65% men) from Sao Paulo, Salvador and Manaus in Brazil. The gender-specific seroprevalences of antibodies against hepatitis B core antigen (anti-HBc) and of the hepatitis B surface antigen (HBsAg) in anti-HBc-positive sera were measured, and risk factors analyzed by gender. The gender-specific seroprevalences of antibodies against HCV (anti-HCV) were measured, but risk factors for HCV were not determined. Anti-HBc and HBsAg seroprevalences were not significantly different in men [101/2,341 (4.31%) and 4/2,229 (0.18%), respectively] and women [65/1,237 (5.25%) and 8/1,169 (0.68%), respectively], whereas the seroprevalence of anti-HCV was higher in women (12/1,238 [0.97%] vs. 9/2,353 [0.38%]; odds ratio [OR] = 2.49; 95% confidence interval [CI]: 1.0-6.0). No significant difference for HBV infection was found across the three study sites or by ethnic group. The seroprevalence of anti-HBc increased with age, but decreased with education level in both genders. Lifetime number of sexual partners was associated with anti-HBc prevalence among men (OR = 1.95; 95% CI: 1.2-3.1), but not women. The seroprevalence of HBV and HCV was low among Brazilian blood donors, and exposure increased with age in both genders. |
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Keywords: | hepatitis B virus (HBV) hepatitis C virus (HCV) epidemiology seroprevalence blood donors Brazil |
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