渐进性咬合紊乱对髁突软骨成纤维细胞生长因子受体1表达的影响

目的：探讨渐进性咬合紊乱对大鼠髁突软骨中成纤维细胞生长因子受体1（Fibroblast growth factor receptor1，FGFR1）表达的影响。方法：建立大鼠渐进性咬合紊乱模型，采用免疫组化方法检测髁突软骨中FGFR1的表达，并通过比较阳性细胞密度，分析FGFR1的表达变化规律。采用SPSS11．0软件包进行统计学分析。结果：FGFR1主要表达在大鼠髁突软骨过渡层和肥大层，增殖层很少；正常组大鼠髁突软骨从6周龄到10周龄FGFR1表达逐渐增强，10周龄后降低．并保持在一个稳定水平；成年组和幼年组实验4、6周时FGFRI的表达均显著低于对照组，实验8周时的表达高于对照组（P〈0．05），幼年组尤为明显，实验2周组与对照组无显著差异。结论：FGFRI参与了大鼠渐进性咬合紊乱所致髁突软骨的改建活动。

Effect of gradually induced occlusal disorders on the expression of FGFR1 of the condylar cartilage in rats

PURPOSE: To investigate the effect of gradually induced occlusal disorders on the expression of FGFR1 in rat condylar cartilage. METHODS: A model of gradually induced occlusal disorders in rat was established.The expression of FGFR1 was detected by SABC immunocytochemistry and analyzed by density of positive cells in condylar cartilage. The data were analyzed using SPSS 11.0 software package. RESULTS: FGFR1-positive chondrocytes were abundant in the maturative layer and hypertrophic layer, but only few FGFR1-positive chondrocytes were found in the proliferative layer. In the control group, the expression of FGFR1 increased from 6-week-old to 10-week-old rats, and then decreased and went stable. In both young and adult group, the expression of FGFR1 in the experimental group was significantly lower at 4, 6 weeks and higher at 8 weeks than that in the control group, especially in the young group(P<0.05). But no difference was found between the experimental group and the control group at 2 weeks in both groups. CONCLUSION: FGFR1 may play an important role in the remodling of condylar cartilage induced by occlusal disorders. Supported by National Natural Science Foundation of China (Grant No.30471909).