| 恩替卡韦治疗慢性重型乙型肝炎疗效观察 |
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| 引用本文： | 韩志启,秦波,张海. 恩替卡韦治疗慢性重型乙型肝炎疗效观察[J]. 临床肝胆病杂志, 2009, 25(3): 188-190 |
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| 作者姓名： | 韩志启 秦波 张海 |
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| 作者单位： | 焦作市第三人民医院传染一科,河南,焦作,454100;焦作市第三人民医院传染一科,河南,焦作,454100;焦作市第三人民医院传染一科,河南,焦作,454100 |
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| 摘 要： | 目的观察恩替卡韦治疗慢性重型乙型肝炎的疗效和安全性。方法36例慢性重型乙型肝炎患者随机分为2组。对照组16例给予常规的综合治疗;治疗组20例,在常规综合治疗的基础上,加用恩替卡韦0.5mg,每日一次,口服4周。分别观察2组治疗前后肝功能和凝血酶原活动度（PTA）、血清HBVDNA水平变化及疗效情况。结果治疗组的总有效率为85.0%,对照组为50.0%,P〈0.01。治疗后4周,与对照组相比,治疗组存活患者的总胆红素降低,凝血酶原活动度（PTA）升高、血清HBVDNA水平降低具有统计学意义P〈0.01。未发现明显的毒副作用。结论恩替卡韦治疗慢性重型乙型肝炎具有较好的疗效和安全性。
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| 关 键 词： | 恩替卡韦 乙型肝炎病毒 慢性重型肝炎 |
Observation on the efficiency and safety of Entecavir on chronic hepatitis B |
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| HAN Zhi-qi,QIN Bo,ZHANG Hai. Observation on the efficiency and safety of Entecavir on chronic hepatitis B[J]. Chinese Journal of Clinical Hepatology, 2009, 25(3): 188-190 |
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| Authors: | HAN Zhi-qi QIN Bo ZHANG Hai |
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| Affiliation: | Department of Infectious Diseases;the Third People's Hospital of Jiaozuo;Henan;454100 China |
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| Abstract: | Objective To observe the efficiency and safety of Extecavir on chronic severe hepatitis B.Methods 36 patients with chronic severe hepatitis B were randomly divided into 2 groups.Control group(n=16) was given the conventional therapy.Treatment group(n=20) was treated with Entecavir,0.5mg daily for four weeks,on the bases of routine treatment.Before and after treatment,hepatic function,prothrombin active(PTA),HBVDNA and efficiency rate of the two groups were detected.Results the results showed that the total ... |
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| Keywords: | Entecavir HBV chronic severe hepatitis |
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