| 4-1BB及其配体在口腔癌免疫治疗中的作用 |
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| 引用本文： | 孙顺涛,杨宏宇. 4-1BB及其配体在口腔癌免疫治疗中的作用[J]. 国际口腔医学杂志, 2009, 36(3) |
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| 作者姓名： | 孙顺涛 杨宏宇 |
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| 作者单位： | 北京大学深圳医院口腔颌面外科,广东,深圳,518036;北京大学深圳医院口腔颌面外科,广东,深圳,518036 |
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| 基金项目： | 国家自然科学基金，广东省自然科学基金，深圳市科技局重点基金 |
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| 摘 要： | 4-1BB和4-1BB配体(4-1BBL)为肿瘤坏死因子/肿瘤坏死因子受体(TNF/TNFR)超家属的成员.研究发现,4-1BB和4-1BBL相互作用产生的共刺激信号在机体肿瘤免疫中起重要作用.本文通过对4-1BB/4-1BBL在共刺激作用的研究,探讨其在口腔癌免疫治疗中的潜在作用.
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| 关 键 词： | 4-1BB/4-1BB配体 共刺激分子 免疫治疗 |
Roles of 4-1BB and 4-1BB ligand in oral cancer immunotherapy |
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| SUN Shun-tao,YANG Hong-yu. Roles of 4-1BB and 4-1BB ligand in oral cancer immunotherapy[J]. Journal of International Stomatology, 2009, 36(3) |
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| Authors: | SUN Shun-tao YANG Hong-yu |
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| Affiliation: | Dept. of Oral and Maxillofacial Surgery;Shenzhen Hospital;Peking University;Shenzhen 518036;China |
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| Abstract: | 4-1BB and 4-1BB ligand(4-1BBL) are members of the tumor necrosis factor/tumor necrosis factor receptor family, which are expressed on T cells and antigen-presenting cells (APC) respectively. In recent study, therapies utilizing the 4-1BB/4-1BBL signaling pathway have been shown to have antitumor effects in a number of model systems. In this report, we focus solely on the role of 4-1BB and its receptor 4-1BBL in costimulation and discuss its potential as a target for the immunotherapy of oral cancer. |
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| Keywords: | 4-1BB/4-1BB ligand costimulatory molecules immunotherapy |
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