复发性生殖器疱疹患者血清IL-2及其受体、IL-6、sICAM-1和sVCAM-1水平的研究

目的：了解复发性生殖器疱疹患者的细胞免疫功能及血清可溶性粘附分子水平。方法：采用ELISA法检测了34例复发性生殖器疱疹患者血清中白介素－2（IL－2）及其可溶性受体（sIL-2R)、白介素－6（IL－6）、细胞间粘附分子－1（sICAM-1)和血管细胞粘附分子－1（sVCAM-1)水平。结果：患者血清IL－2及IL－6明显低于正常对照（P＜0．01），sIL-2R,sICAM-1和sVCAM-1明显高于对照（P＜0．05）；发作期与缓解期的患者各项指标比较无显著性差异（P＞0．05）。结论：复发性生殖器疱疹患者存在细胞免疫缺陷和血清粘附分子水平，可能与本病反复发作以及发生炎症反应有关。

Study of Serum Levels of Interlukin-2 and Its Receptor, Interlukin-6,sICAM-1,sVCAM-1 in Patients with Recurrent Genital Herpes

Objective To study cellular immunity status and serum levels of adhesion molecules of patients with recurrent genital herpes.Methods Serum levels of interlukin 2 and its soluble receptor,interlukin 6, sICAM 1, sVCAM 1 were measured by ELISA in 34 patients with recurrent genital herpes. Results The serum levels of IL 2 and IL 6 were significantly lower in patients than in healthy controls ( P <0.01). The levels of sIL 2R, sICAM 1 and sVCAM 1 were significantly higher in patients than in controls ( P <0.05). No significant differences were seen in all variables of patients in relapse phase and remission phase ( P >0.05).Conclusion There are cellular immunity deficiency and high serum levels of adhesion molecules in patients with recurrent genital herpes, and these changes may be related to the recurrence of genital herpes and the development of inflammatory reaction.