Opposite effects of chlordiazepoxide and serotonin receptor antagonists on morphine-induced locomotor stimulation in mice |
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Authors: | Mario Sansone |
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Affiliation: | (1) CNR, Istituto di Psicobiologia e Psicofarmacologia, Via Reno 1, I-00198 Roma, Italy |
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Abstract: | Chlordiazepoxide and two serotonin receptor antagonists showed opposite effects when tested for their influence on morphine-induced locomotor stimulation in mice. Chlordiazepoxide enhanced morphine-induced hyperactivity, which was antagonized by cyproheptadine and mianserin. The results indicate that the enhancement of morphine-induced locomotor stimulation is not attributable to an antiserotonergic action of the benzodiazepine compound. |
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Keywords: | Morphine Chlordiazepoxide Serotonin antagonists Locomotor activity Mice |
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