Synthesis and biological properties of 1 beta-methylcarbapenems with N-methylpyrrolidinylthio group at C-2 position. |
| |
| Authors: | M Sunagawa H Matsumura T Inoue H Yamaga M Fukasawa |
| |
| Affiliation: | Research Laboratories, Sumitomo Pharmaceuticals Co., Ltd., Osaka, Japan. |
| |
| Abstract: | A series of 1 beta-methylcarbapenem compounds, which have a 5'-substituted-N-methylpyrrolidin-3'-ylthio group as a C-2 side chain, have been prepared and their biological properties were investigated. Substitution with a methyl group on the nitrogen atom in the C-2 side chain effectively enhanced stability to renal dehydropeptidase-I as well as introduction of methylene spacer between the aminocarbonyl group and the pyrrolidine ring of the 5'-aminocarbonylpyrrolidin-3'-ylthio group. |
| |
| Keywords: | |
|
|
