丹葛滴丸成型的工艺研究

目的：优选丹葛滴丸成型工艺。方法：将提取药液浸膏与适宜基质按一定配比混和,滴入不相混溶的冷凝液中,收缩冷凝成丸,采用单因素对比和正交实验设计来优选滴丸成型工艺。结果：通过多种条件的考察,优选出制成滴丸的最佳工艺：选用基质：聚乙二醇-6 000（PEG6 000）聚乙二醇-4 000（PEG4 000）=2 1,冷凝液：液体石蜡,基质与提取物的比例为3 1,料温：85℃,冷凝液温度：5-10℃,滴距：选择6 cm较好。结论：优选得到的工艺可行,成品得率高,符合滴丸剂的质量标准。

Study on Moulding Process of Dange Drop Pills

Objective：To study molding process of Dange Drop Pills.Methods：Liquid extract will be mixed with groundmass according to certain proportion,dripped into immiscible condensate liquids and condensed into a pill.Then the orthogonal experiment was used to determine the optimum preparation technology according to the hardness of drop pills,appearance and weight variations.Results：The optimum preparation technology was selected according to a variety of conditions.Groundmass：PEG6000PEG4000 =21;condensate liquids：liquid paraffin;the proportion of groundmass and extract：31;temperature of drug：85 ℃;the temperature of condensate liquid：5-10 ℃,the dropping distance：6 cm.Conclusion：This preferable processing technology was efficient and feasible with high yield of finished products,which is in line with quality standards of pills.