参仙漱口液联合伊曲康唑治疗顽固性口腔念珠菌病临床研究

目的：观察参仙漱口液联合伊曲康唑治疗顽固性口腔念珠菌病的临床疗效。方法：100例确诊患者,随机平均分为两组。对照组采用伊曲康唑片100 mg,日1次,口服,14 d为1疗程;治疗组在对照组的基础上加用参仙漱口液含漱,20-30 mL/次,4-6次/d,连用14 d为1疗程。疗程结束后统计疗效,并随访3月观察复发率。结果：治疗组有效率为96.0%,明显高于对照组（82.0%）,两组有效率比较,差异有统计学意义（P〈0.05）;随访3月,治疗组复发率为10.5%,明显低于对照组（42.3%）,两组有效率比较,差异有统计学意义（P〈0.05）。结论：参仙漱口液联合伊曲康唑治疗顽固性口腔念珠菌病临床疗效显著。

Clinical Study on Shenxian Shukou Liquid Combined with Itraconazole for Treating Intractable Oral Candidiasis

Objective：To observe clinical effects of shenxian shukou liquid combined with itraconazole for treating intractable oral candidiasis.Methods：100 diagnosed patients were randomized into two groups.The control group adopted 100 mg itraconazole,qd,orally with 14 days as one course of treatment;treatment group was added Shenxian Shukou Liquid Gargle based on the treatment of control group,20-30 mL per time,4-6 times per day with 14 days as one course of treatment.After the completion of treatment,therapeutic effects were calculated and 3-month follow-up visit was performed to observe reoccurrence rate.Methods：The effective rate of treatment group was 96.0%,markedly higher than that of control group（82.0%）.Compared with the effective rates of both groups,there was the significant difference（P0.05）;3-month follow-up visit showed that reoccurrence rate of treatment group was 10.5%,which was obviously lower than that of control group（42.3%）.Compared with the effective rates of both groups,there was a significant difference（P0.05）.Conclusion：The combination of shenxian shukou liquid and itraconazole has conspicuous clinical effects for treating intractable oral candidiasis.