| Abstract: | The absolute and relative (per 106 spleen cells) number of antibody-forming cells (AFC) in the spleen of CBA mice was found to be reduced by half of the 1st, 4th, and 7th days after acute hypoxia (12 h, 6700 m) and on the 1st and 4th days after the end of exposure to chronic hypoxia (16 h daily for 16 days, 6700 m). By the 7th day after the end of exposure to chronic hypoxia the number of AFC in the spleen of the mice was back to normal. One of two injections of erythropoietin reduced the absolute and relative number of AFC in the spleen of the posthypoxic mice by 33–50% compared with control animals.Laboratory of Regulation of Immunopoiesis, Institute of Clinical and Experimental Medicine, Siberian Branch, Academy of Medical Sciences of the USSR, Novosibirsk. (Presented by Academician of the Academy of Medical Sciences of the USSR V. P. Kaznacheev.) Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 85, No. 5, pp. 565–567, May, 1978. |
